Bisoprolol is a pharmaceutical drug that works as a selective beta-
adrenergic receptor blocker located in the heart and blood vessel walls, and
is a class of drugs mainly used in cardiovascular diseases. It is a specific
selective blocker of β1 adrenergic receptors.
o Chemical formula: C18H31NO4
o Methods of administering the drug: oral
o Treats: heart attack, high blood pressure, congestive heart failure, angina,
supraventricular tachycardia, and high blood pressure.
Diabetes: beta-blockers may mask important signs of acute hypoglycaemia (e.g. tachycardia, tremor), and increase
incidence and severity of hypoglycaemia but data are conflicting; beta1-selective beta-blockers (e.g. atenolol), are
preferable as they have been shown to be safe and effective in patients with type 2 diabetes.
Severe peripheral vascular diseases, Raynaud's syndrome: may impair peripheral circulation and exacerbate
symptoms.
This drug shouldn't be taken in these cases:
Reversible airways disease (e.g. asthma, COPD)
Bradycardia (45–50 beats/minute), sick sinus syndrome, second or third degree atrioventricular block, shock
(cardiogenic and hypovolaemic), severe hypotension; uncontrolled heart failure.
It's important to tell your doctor your history with diseases, in order to prevent any contraindications effect.
This drug is taken orally as follow:
Initially, 1.25 mg once daily for 1 week; increase dose if well tolerated according to the following steps: 2.5 mg once
daily for a week, then 3.75 mg once daily for a week, then 5 mg once daily for 4 weeks, then 7.5 mg once daily for4 weeks, then 10 mg once daily for maintenance. Slower dose titration may be appropriate in some patients.
medicines for high blood pressure – the combination with bisoprolol can sometimes lower your blood pressure too much, which may make you feel dizzy or faint. If this keeps happening to you, tell your doctor as they may change your dose.
other medicines that can lower your blood pressure, such as some antidepressants, nitrates (for chest pain), baclofen (a muscle relaxant), medicines for an enlarged prostate gland like tamsulosin, or Parkinson's disease medicines, such as co-careldopa and levodopa
non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen – they can stop bisoprolol working as well as it should
medicines for diabetes – bisoprolol may make it more difficult to recognise the warning signs of low blood sugar
medicines for allergies, such as ephedrine, noradrenaline or adrenaline
medicines for asthma or chronic obstructive pulmonary disease (COPD)
Store at room temperature away from light , heat and moisture.
-Do not store in the bathroom.
-Do not keep outdated medicine or medicine no longer needed.
-Keep out all medications away from children and pets.
-Ask your health care professional or pharmacist how to throw
away any medicine you do not use.
-Do not flush medications down the toilet or pour them into a
drain unless instructed to do so.
The active substance is bisoprolol fumarate. Each tablet contains 1.25 mg, 2.5 mg, 3.75 mg, 5 mg 7.5 mg or 10 mg bisoprolol fumarate. The other ingredients are cellulose, microcrystalline (PH 102); starch, pregelatinised; crospovidone (type A); silica, colloidal anhydrous; magnesium stearate.